12/4/2023 0 Comments Lichtenberg lightning strike scarHere, we describe the protein-level molecular characterisation of LFs in a patient that suffered a high-voltage electrical injury from an alternating current switchgear and presented with non-blanching red marks consistent with LFs over his right flank. Our group recently reported a case of LFs following a lightning strike injury and discussed its possible pathophysiology ( 10, 12). They arise from a positive discharge on the skin that, in the case of negatively charged lightning, is speculated to be generated by flashover from a nearby protrusion at earth potential ( 11). LFs appear to be a mysterious infrequent, transient sequelae of lightning strike injuries and have been sporadically reported in several case reports ( 1– 10). The true pathophysiology of LFs remains unknown ( 2, 3). They received their name from Georg Lichtenberg, who in 1777 first described them whilst conducting static electricity experiments. Lichtenberg figures (LFs), also known as ferning pattern, feathering, keraunographic markings or arborescent burns, are a pathognomonic skin sign for a lightning strike injury ( 1). Our results provide an initial molecular and cellular insight into the tissue response associated with LFs. These changes in the LF-affected skin were associated with extravasation of red blood cells from dermal vessels. Our results demonstrated an increase in dermal T-cells and greatly increased expression of the iron-binding glycoprotein lactoferrin by keratinocytes and lymphocytes. The aim was to characterise the tissue response of LFs by performing untargeted non-labelled proteomics and immunohistochemistry on paraffin-embedded sections of skin biopsies taken from the area of LFs at presentation and at 3 months follow-up. Their true pathophysiology has remained a mystery and only once before described following an electical injury. LFs, also known as ferning pattern or keraunographic markings, are a pathognomonic skin sign for lightning strike injuries. We describe a case of Lichtenberg Figures (LFs) following an electrical injury from a high-voltage switchgear in a 47 year-old electrician. 5Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.4Helsinki Wound Healing Centre, Helsinki University Hospital, Helsinki, Finland.3Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.2Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Hospital Diagnostic Center, HUSLAB, Helsinki, Finland.1Department of Plastic Surgery, Helsinki Burn Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.Andrew Lindford 1 * Susanna Juteau 2 Viljar Jaks 3 Mariliis Klaas 3 Heli Lagus 4 Jyrki Vuola 1 Esko Kankuri 5
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |